Preventing Chrome hijacks from coming back

It's easy enough to remove extensions in Chrome, but to prevent the really obnoxious ones from coming back again, look at paths in entries under HKEY_LOCAL_MACHINE\SOFTWARE\Wow6432Node\Google\Chrome\Extensions\
Basically anything in C:\Users\USERNAME\AppData\Local\CRE or C:\Users\USERNAME\AppData\Local\Temp
can go.  My thanks to Mike for the helpful advice.