*bold*
bold
_italic_
italic
~strikethrough~
@@ *not bold* (note the space after the two at signs, and that this must be the first thing in a message)
*not bold*
preformatted
Preformatting also overrides other markup, for example
!! *not bold*
*not bold*
Preformatting also respects whitespaces, for example
!! above
below
above
below
Of course Skype also supports /me, like most chat clients do these days
/me yawns
[user name] yawns
[user name], will be whatever your name is in Skype (not your username)
And since 6.22.81.105, you can also enable/disable the markup feature with
/wikimarkup on/off